3-FORMYL INDOLEACETIC ACID
N-Acetic acid-indole-3-carboxaldehyde
CAS: 138423-98-0
Molecular Formula: C11H9NO3
3-FORMYL INDOLEACETIC ACID - Names and Identifiers
3-FORMYL INDOLEACETIC ACID - Physico-chemical Properties
| Molecular Formula | C11H9NO3 |
| Molar Mass | 203.19 |
| Density | 1.30±0.1 g/cm3(Predicted) |
| Melting Point | 197-200°C(lit.) |
| Boling Point | 458.5±25.0 °C(Predicted) |
| Flash Point | 231.1°C |
| Vapor Presure | 3.34E-09mmHg at 25°C |
| Appearance | Solid |
| BRN | 5431204 |
| pKa | 4.15±0.10(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
| Sensitive | Air Sensitive |
| Refractive Index | 1.621 |
| MDL | MFCD00452923 |
| Physical and Chemical Properties | Storage Conditions: 2-8 ℃ WGK Germany:3 |
3-FORMYL INDOLEACETIC ACID - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 8-10-23 |
| HS Code | 29339900 |
| Hazard Class | IRRITANT |
3-FORMYL INDOLEACETIC ACID - Introduction
Indole formaldehyde resin was synthesized by coupling to ammonia resin. Amines and derivatives can be fixed by the reductive amination reaction of the polyaldehyde resin. Mild cleavage with 50% TFA 1
Last Update：2022-10-16 17:13:45
3-FORMYL INDOLEACETIC ACID - Reference Information
| Uses | N-acetic acid -3-indole formaldehyde is an organic intermediate. |
| Preparation | N-acetic acid -3-indole formaldehyde can be prepared by the nucleophilic substitution reaction of 3-formyl indole and ethyl bromoacetate (3-formyl indole -1-yl) ethyl acetate, and then hydrolyze the ester group to prepare N-acetic acid -3-indole formaldehyde. 3-formyl indole (10g,69mmol) was dissolved in N,N-dimethylformamide (100mL), and the temperature was kept below 15 ℃ under external cooling under nitriding atmosphere. Sodium hydride (60%,3.0g,76mmol in mineral oil) was added in batches. Then, after 30 minutes, ethyl bromoacetate (8.4mL,76mmol) of N,N-dimethylformamide (15mL) solution was added dropwise, and the resulting mixture was stirred at room temperature for 16 hours. Concentrate the mixture in vacuum so that the residue is divided between water (300mL) and ethyl acetate (2 × 150mL). The organic extract was combined, washed with saturated ammonium chloride aqueous solution (100mL), dried (MgSO4), and concentrated in vacuum to obtain 15.9g (quantitative) (3-formylindole-1-yl) ethyl acetate, an oil. 1H-NMR(CDCl3):δH = 1.30(3H,t),4.23(2H,q),4.90(2H,s),7.3(3H,m),7.77(1H,s),8.32(1H,d),10.0(1H,s). will (3-formyl indole -1-yl) ethyl acetate (15.9g,69mmol) is dissolved in 1,4-dioxane (100mL), 1N sodium hydroxide (10mL) is added, and the obtained mixture is stirred at room temperature for 4 days. Water (500mL) was added and the mixture was washed with diethyl ether (150mL). The aqueous phase was acidified with 5N hydrochloric acid and extracted with ethyl acetate (250 150mL). The organic extract was combined, dried (MgSO4) and concentrated in vacuum to obtain 10.3g(73%) N-acetic acid -3-indole formaldehyde as solid. 1H-NMR(DMSO-d6):δH=5.20(2H,s),7.3(2H,m),7.55(1H,d),8.12(1H,d),8.30(1H,s),9.95(1H,s),13.3(1H,bs). |
Last Update：2024-04-09 21:21:28
Supplier List
Product Name: N-Acetic acid-indole-3-carboxaldehyde Request for quotation
CAS: 138423-98-0
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
CAS: 138423-98-0
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Spot supply
Product Name: N-Acetic acid-Indole-3-Carboxaldehyde Visit Supplier Webpage Request for quotationCAS: 138423-98-0
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Spot supply
Product Name: (3-Formyl-1-indolyl)acetic acid Visit Supplier Webpage Request for quotationCAS: 138423-98-0
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: (3-Formyl-1-indolyl)acetic acid Visit Supplier Webpage Request for quotationCAS: 138423-98-0
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: (3-Formyl-1-indolyl)acetic acid Visit Supplier Webpage Request for quotationCAS: 138423-98-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Product Name: N-Acetic acid-indole-3-carboxaldehyde Request for quotation
CAS: 138423-98-0
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
CAS: 138423-98-0
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Spot supply
Product Name: N-Acetic acid-Indole-3-Carboxaldehyde Visit Supplier Webpage Request for quotationCAS: 138423-98-0
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Spot supply
Product Name: (3-Formyl-1-indolyl)acetic acid Visit Supplier Webpage Request for quotationCAS: 138423-98-0
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: (3-Formyl-1-indolyl)acetic acid Visit Supplier Webpage Request for quotationCAS: 138423-98-0
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: (3-Formyl-1-indolyl)acetic acid Visit Supplier Webpage Request for quotationCAS: 138423-98-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
3-FORMYL INDOLEACETIC ACID
CYCLOPENTYLTRICHLOROSILANE
5-((Z)-(5-氟-2-吲哚酮-3-基)甲基)-2,4-二甲基吡咯-3-羧酸
国外镍钼加氢转化脱硫催化剂(部分)
2,6-二溴吡啶-4-甲醇
C.I.活性红2
Reactron Yellow 3RS
alpha-熊果甙
4,4-二甲氧基-2-丁酮
TRIETHYLENE GLYCOL TOSYLATE
CYCLOPENTYLTRICHLOROSILANE
5-((Z)-(5-氟-2-吲哚酮-3-基)甲基)-2,4-二甲基吡咯-3-羧酸
国外镍钼加氢转化脱硫催化剂(部分)
2,6-二溴吡啶-4-甲醇
C.I.活性红2
Reactron Yellow 3RS
alpha-熊果甙
4,4-二甲氧基-2-丁酮
TRIETHYLENE GLYCOL TOSYLATE